Journal: Journal of Neuroinflammation
Article Title: Reduced acute neuroinflammation and improved functional recovery after traumatic brain injury by α-linolenic acid supplementation in mice
doi: 10.1186/s12974-016-0714-4
Figure Lengend Snippet: Effect of low or adequate α-linolenic acid diet on motor and cognitive changes after TBI. a , b Impaired motor performance in the rotarod ( a ) and beam walk tests ( b ) due to TBI was recovered faster in mice on adequate α-linolenic acid (ALA) diet compared to those on the low ALA diet that had less brain DHA. c Mice on adequate ALA diet showed more freezing after contextual fear conditioning compared to the mice on low ALA diet for both sham and TBI mice. *** p < 0.001, ** p < 0.01, * p < 0.05 compared to the respective low ALA diet group. Data are expressed as mean ± SEM. n = 8–14
Article Snippet: Mice were individually placed inside the fear conditioning chamber (Freeze Monitor, San Diego Instruments, San Diego, CA, USA) on the first day and allowed to explore for 5 min. On the following day, mice were given two shocks at 120 and 150 s after being introduced into the fear conditioning chamber and were taken out of the chamber 60 s after the last shock.
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